BARDA DxR2 Funding Opportunity: Develop and Deploy Biothreat Diognostics

Tyler Maxwell
Jun 27
2 min read

The Biomedical Advanced Research and Development Authority (BARDA) is investing in the next generation of point-of-care (POC) biothreat diagnostics through the DxR2 (Diagnostic Rapid Response) initiative. This OTA-funded opportunity supports the design, validation, and manufacturing transfer of diagnostic tests targeting high-priority biological threats.

This is a compelling opportunity for diagnostic companies to partner with BARDA and advance technologies critical to public health preparedness.

Solicitation Overview

Opportunity Name: Biothreat Diagnostic Rapid Response (DxR2)
Solicitation Number: RRPV-25-06-DxR2
Issuing Agency: BARDA, via the Rapid Response Partnership Vehicle (RRPV)
Contracting Mechanism: Other Transaction Agreement (OTA)
Total Available Funding: $40M
Base Period Duration: 36 Months
Proposal Due Date: August 4, 2025 @ 1:00 PM ET

Proposal Requirements

Offerors must submit the following documents using BARDA provided templates:

Technical Proposal (30-page limit + required attachments)
Cost Proposal (narrative and Excel cost breakdown)
Statement of Work / Milestone Payment Schedule

Program Phases & Strategic Goals

Base Period (Required)

Develop diagnostics for one or more of the following: Glanders, Botulism toxxin (BoNT), Tularemia, Typhus, Smallpox, Plague
Execute FDA clearance strategy and transfer to U.S. manufacturing
Complete kit and sample stability studies and capacity assessments

Option Period I

Maintain warm-base surge capacity
Manufacture kits for stockpiling, training, and emergency use

Option Period II

Implement just-in-time manufacturing upgrades
Enable rapid scale-up and deployment for public health emergencies

How Rosewater Consulting Can Help

At Rosewater Consulting, we specialize in helping diagnostic and life science companies secure government funding through OTA and R&D-focused solicitations. We offer:

End-to-end proposal strategy and compliance
Technical narrative support and cost structure modeling
Project management planning and milestone development